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Middle East Journal of Digestive Diseases، جلد ۱۳، شماره ۳، صفحات ۲۲۲-۲۲۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Comparison between Hybrid, Reverse Hybrid, and Non-Bismuth Levofloxacin Quadruple Regimens for Helicobacter Pylori Infection in Egypt: A Randomized Trial |
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| چکیده انگلیسی مقاله |
Background : The prevalence of Helicobacter pylori in developing countries is 50.8%, with the highest occurrence presented in Africa (79.1%). It increases the risk of chronic gastritis, peptic ulcer, cancer stomach, and lymphoma. Standard treatment for Helicobacter pylori eradication is below 80% and evaluation of alternative lines of treatment is needed. We aimed to compare the hybrid, reverse hybrid, and levofloxacin quadruple therapies as first-line therapy in Egypt. Methods: This was an interventional randomized trial at the internal medicine department clinic. A total number of 330 subjects were selected according to the inclusion criteria. They were divided into three groups: Group 1 (110 subjects had received a reverse hybrid regimen), Group 2 (110 subjects had received a hybrid regimen), and Group 3 (110 subjects had received a non-bismuth levofloxacin quadruple regimen). Results : Group 3 had a significantly lower eradication rate of 82.7% versus 92.7% and 91.8% in groups 1 and 2, respectively. There were non-significant differences in the incidence rates of adverse events among the three groups. Conclusion: Both the reverse hybrid and hybrid groups had good eradication rates in the Egyptian population, but non-bismuth levofloxacin quadruple therapy did not obtain sufficient eradication rates. |
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| کلیدواژه‌های انگلیسی مقاله |
Hybrid therapy, Reverse hybrid therapy, Helicobacter pylori, Eradication therapy, Levofloxacin, omeprazole, nitazoxanide, and doxycycline (LOND) therapy |
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| نویسندگان مقاله |
| Ayman Fathy El Sayed
Zagazig University
| Ayman Magd Eldin Mohammad Sadek
Zagazig University
| Walid Ahmed Ragab Abdelhamid
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| نشانی اینترنتی |
http://mejdd.org/index.php/mejdd/article/view/2393 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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