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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۲۱، شماره ۴، صفحات ۳۳۰-۳۳۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
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| چکیده انگلیسی مقاله |
Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, which its etiology and pathogenesis are unclear. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular cross-talk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: Peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals. Serum samples were prepared from LP patients, using a commercial ELISA Kit, IL-22 concentration was measured in each serum sample. The obtained data were then analyzed using the Kruskal-Wallis one-way analysis of variance. Results: IL-22 serums level was significantly higher in patients with oral lichen planus than the healthy control group (p < 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p = 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral Lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus. |
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| کلیدواژه‌های انگلیسی مقاله |
IL-22, Oral lichen planus, Cutaneous lichen planus, serum |
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| نویسندگان مقاله |
Maryam Mardani |
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiva Torabi Ardakani |
Dept. of Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Ladan Dastgheib |
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasrin Hamidizadeh |
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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| نشانی اینترنتی |
https://dentjods.sums.ac.ir/article_46238_a1a9ed1ad147ac8fc934a460e022de24.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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