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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۲۲، شماره ۳، صفحات ۱۸۰-۱۸۶
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عنوان انگلیسی Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients
چکیده انگلیسی مقاله Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients.
کلیدواژه‌های انگلیسی مقاله IL-17A, Polymorphisms Type 1 Diabetes, Chronic periodontitis, ethnicity
نویسندگان مقاله Sasi Kumar PKS |
Dept. of Periodontics, JKKN Dental College and Hospital, Tamilnadu DrMGR Medical University, Chennai.

Sheeja Varghese |
Dean & HOD, Dept. of Periodontics, Saveetha Dental College and Hospital, Chennai, Tamilnadu, India.

Thanga Kumaran S |
Dept. of Periodontics, JKKN Dental College and Hospital.

Jaga Desaan N |
Dept. of Prosthodontics, JKKN Dental College and Hospital.

Lambo Daran G |
Dept. of Prosthodontics. Meenakshiammal Dental College

نشانی اینترنتی https://dentjods.sums.ac.ir/article_47141_9ebba021d457fc36530e98b2deb42068.pdf
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