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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۲۲، شماره ۳، صفحات ۱۷۵-۱۷۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis |
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| چکیده انگلیسی مقاله |
Statement of the Problem: Traditional clinical criteria are usually not sufficient to determine the sites of active periodontal disease, monitoring response to treatment, or measuring the susceptibility to future disease development. Past studies have shown that heat shock protein 70 (HSP70) are involved in the etiology of periodontal disease. Purpose: The aim of this study was to evaluate the level of HSP70 in saliva of patients with chronic periodontitis (CP). Materials and Method: In our case-control study, the saliva samples of 45 patients with CP and 45 age- and sex-matched healthy subjects were collected. Salivary HSP70 was measured by enzyme-linked immunosorbent assay method. The results were analyzed based on statistical tests. The software which used in this study was SPSS 16 and statistically significant difference was considered when p < 0.05. Results: In this study, the mean salivary HSP70 level was 2.81±0.61ng/ml in the patient group and 1.96±0.77ng/ml in the healthy group, with a significant difference (p < 0.05). Also, the results of spearman correlation analysis showed a positive correlation between salivary HSP 70 and clinical periodontal index. Conclusion: The results of this study showed that the salivary HSP70 level in patients with CP is higher than healthy subjects. As a result, salivary HSP70 can be considered as a marker in the pathogenesis of CP. |
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| کلیدواژه‌های انگلیسی مقاله |
Chronic periodontitis, HSP70 heat-shock proteins, Saliva |
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| نویسندگان مقاله |
Paria Motahari |
Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Solmaz Pourzare Mehrbani |
Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamed Jabbarvand |
Dentist, Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
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| نشانی اینترنتی |
https://dentjods.sums.ac.ir/article_47140_6aeee0ac4d5f1e7790b5b741c9fa3aba.pdf |
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| زبان مقاله منتشر شده |
en |
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