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Nanomedicine Journal، جلد ۸، شماره ۳، صفحات ۱۶۶-۱۷۸
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چکیده فارسی مقاله
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عنوان انگلیسی Application of Manganese Oxide (MnO) nanoparticles in multimodal molecular imaging and cancer therapy: A review
چکیده انگلیسی مقاله Contrast agents (CAs) play a critical role in high-resolution magnetic resonance imaging (MRI) applications to enhance the low intrinsic sensitivity of MRI. Manganese oxide nanoparticles (MnO) have gotten developing consideration as substitute spin−lattice (T1) MRI CAs as a result of the Gd-based CAs which are related with renal fibrosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide NPs. In this review, previous developments in the usage of MnO nanoparticles as MRI CAs for cancer theranostic applications such as developments in toxicological properties, distribution and tumor microenvironment (TME)-responsive biomaterials were reviewed. A literature search was accomplished to discover distributed research that elaborates the use of MnO in multimodal imaging and therapy. In the current study, the electronic search including PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed dependent on Mesh key words. CAs can significantly improve the imaging contrast among the lesions and normal tissues. In this study we generally concentrate on typical advancements of MnO nanoparticles about properties, bimodal or multimodal imaging, and therapy. Numerous researches have demonstrated MnO-based nanostructure produce considerable biocompatibility with the lack of cytotoxicity. Therefore, remarkable features improved photothermal therapy, chemotherapy and Chemodynamic therapy.
کلیدواژه‌های انگلیسی مقاله magnetic resonance imaging, MnO nanoparticles, Multimodal imaging, Nanomaterial
نویسندگان مقاله | Mehdi Khalilnejad
Department of Medical Physic, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Tohid Mortezazadeh
Department of Medical Physic, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Ramin Ghasemi Shayan
Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_18098.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Paper
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