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Bulletin of Emergency and Trauma، جلد ۱۰، شماره ۱، صفحات ۴۴-۴۸
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عنوان انگلیسی Severe Acute Kidney Injury Secondary to Immunoglobulin Infusion in Life-Threatening Guillain Barre Syndrome
چکیده انگلیسی مقاله Immunoglobulin infusion (IVIG) is one of the first line therapy in Guillain Barre Syndrome (GBS). Several medical complications are associated with GBS (pneumonia, sepsis, deep vein thrombosis, dysautonomy). Acute kidney injury (AKI) is an uncommon complication during IVIG infusion. Several risk factors were associated with AKI during IVIG. These are an older age, previous renal disease, concomitant use of nephrotoxic agents, diabetes mellitus, hypovolemia, sepsis or using of IVIG that contained in its preparation sucrose or mannitol as stabilizers to avoid precipitation and aggregation. Infusion rate and total dose play a determinant role. The most important pathophysiological mechanism of AKI are the osmotic stress applied to the epithelium of proximal tubules and glomeruli. The osmotic overload is principally generated by IVIG stabilizers (sucrose). In general, AKI is reversible but approximately 30% hemodialysis is necessary. It is essential to respect doses, infusion rates and closely monitoring renal function parameters during IVIG infusion.
کلیدواژه‌های انگلیسی مقاله Guillain Barre Syndrome, Acute Flaccid Paralysis, Immunoglobulin, immunotherapy, Acute Kidney injury (AKI)
نویسندگان مقاله José David D Orquera |
Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina

Maria Marta Pernasetti |
Department of Nephrology, Sanatorio Pasteur, Catamarca, Argentina

Patricia Ojeda |
Department of Nephrology, Sanatorio Pasteur, Catamarca, Argentina

Griselda Aguero |
Department of Neurology, Sanatorio Pasteur, Catamarca, Argentina

Daniel Agustin Godoy |
Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina

نشانی اینترنتی https://beat.sums.ac.ir/article_47484_7e829132c33ebe9f7d61d9ccaaaa7ef8.pdf
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