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Basic and Clinical Neuroscience، جلد ۱۱، شماره ۴، صفحات ۴۹۱-۴۹۸
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چکیده فارسی مقاله
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عنوان انگلیسی Immune Checkpoint Molecules in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
چکیده انگلیسی مقاله Introduction: Primary Diffuse Large B Cell Lymphoma of CNS (PCNSL) is a rare variant of Diffuse Large B Cell Lymphoma (DLBCL) and presents with an aggressive clinical course and usually resistant to commonly used therapy regimens. Recently, role of immune checkpoint molecules including PD-1 and PD-L1 confirmed in some solid tumors and lymphoma resulting tumor cells escape the immune system and help to survive and to spread. Inhibitors of PD-1 and PD-L1 have shown lasting responses in several solid and some hematological tumors, while limited studies evaluate checkpoint molecules on PCNSL. Method: In this study, we investigated PD-1 and PD-L1 expression by immunostaining on 71 patients with PCNSL and correlation with demographic data, location of the tumor, proliferation rate, cell of origin, and CD8 positive T cell infiltration in tumor microenvironment.  Results: 16 from71 showed PD-1 expression, while PD-L1 expression were 42/71. No association was determined between PD-1/PD-L1 expression and gender, cell of origin, and proliferation rate, but a highly significant difference was determined between the infiltration of CD8 positive T cells in two groups of PD-1/PD-L1 positive and negative.  Conclusion: This study revealed expression of check point molecules in remarkable number of PCNSL which may open new therapeutic recommendations in this aggressive lymphoma type.
کلیدواژه‌های انگلیسی مقاله Primary large B-cell lymphoma, CNS, Immune checkpoint, Programmed death-1 (PD-1), Programmed death-1 ligand (PD-L1), Central nervous system
نویسندگان مقاله | Ahmad Monabati
Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.


| Pardis Nematollahi
Department of Pathology, Cancer Prevention Research Center, Isfahan University of Medical Science, Isfahan, Iran.


| Amirreza Dehghanian
Department of Pathology, Molecular Pathology and Cytogenetics Division, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.


| Akbar Safaei
Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.


| Alireza Sadeghipour
Department of Pathology, Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.


| Sajjadeh Movahedinia
Department of Pathology, Faculty of Medicine, Kerman University of Medical Science, Kerman, Iran.


| Maral Mokhtari
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-2542-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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