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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۳، صفحات ۳۸۳-۳۹۴
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عنوان انگلیسی β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol
چکیده انگلیسی مقاله Introduction: The increasing cases of Alzheimer Disease (AD) has caused numerous problems. The risk of developing AD increases in menopausal women, too. Apigenin and β-estradiol are effective antioxidant and neuroprotective agents. We conducted the present study to explore their combined effects on β-amyloid plaque formation, memory, and learning in ovariectomized rats. Methods: Forty-two Wistar rats were randomly assigned into 6 groups: 1) ovariectomized (OVX), 2) OVX + apigenin, 3) OVX + β-estradiol, 4) OVX + apigenin +  β-estradiol, 5 &6) vehicle shams for E2 and API , and 7) surgical sham. Treatment was done with apigenin and β-estradiol. Then, we studied the formation of β-amyloid plaques, neuronal density in the hippocampus area, apoptosis, memory, and learning. Results: Findings showed the significant formation of β-amyloid plaques in the hippocampus of OVX animals and their memory impairment. Apigenin and β-estradiol significantly reduced the number of β-amyloid plaques, as well as the symptoms of memory impairment and learning, and decreased the expression of caspase-3 in treated animals. Conclusion: Accordingly, β-estradiol and apigenin could have more potent therapeutic effects on AD.
کلیدواژه‌های انگلیسی مقاله β-Amyloid plaques, β-Estradiol, Apigenin, Ovariectomy
نویسندگان مقاله | Seyed Behnamedin Jameie
Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.


| Abbas Pirasteh
Department of Psychology, Faculty of Humanities, Firoozabad Branch, Islamic Azad University, Fars, Iran.


| Ali Naseri
Department of Psychology, Faculty of Humanities, Firoozabad Branch, Islamic Azad University, Fars, Iran.


| Melika Sadat Jameie
Department of Anatomy, Faculty of Medicine, Shahid Behshti University of Medical Sciences, Tehran, Iran.


| Mona Farhadi
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.


| Javad Fahanik Babaee
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Leila Elyasi
Department of Anatomy, Neuroscience Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-2634-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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