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Caspian Journal of Internal Medicine، جلد ۱۲، شماره Case Supplement، صفحات ۳۵۹-۳۶۲
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عنوان انگلیسی Creutzfeldt-Jakob disease: A case report
چکیده انگلیسی مقاله Background: Creutzfeldt-Jakob disease (CJD) as a life-threatening neurodegenerative disorder is not usually diagnosed in early stages of the disease because of a variety in its clinical manifestations. This study aimed to present a middle-aged woman with psychiatric symptoms who ultimately was diagnosed as a CJD case. Case presentation: This 48-year-old woman had progressive symptoms of depressed mood, decreased sleep and appetite and mutism which started two months before the first visit. Gradually, slowness in movements, dysarthria and decreased performance were observed. Subsequently, when antidepressant and antipsychotic drugs were prescribed other symptoms such as ataxia and rigidity manifested in the patient. The problem list which led to final confirmation of the disease included non-specific neuropsychological presentations, hypersignality in caudate and putamen areas in brain MRI, generalized high frequency sharp waves in EEG, and protein 14-3-3 identification in cerebrospinal fluid. Conclusion: Although CJD is not a common disease, it should be considered in differential diagnoses whenever neuropsychological manifestations, especially progressive decline in cognition, along with symptoms such as visual hallucinations, myoclonus and ataxia are observed in the patient.
کلیدواژه‌های انگلیسی مقاله Creutzfeldt-Jakob Disease, Cognitive Decline, Neurodegenerative Disorders
نویسندگان مقاله | Razieh Salehian
Mental Health Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Farzad Sina
Department of Neurology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Sussan Moudi
Social Determinants of Health Reseach Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
نشانی اینترنتی http://caspjim.com/browse.php?a_code=A-10-113-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurology
نوع مقاله منتشر شده case report
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