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Caspian Journal of Internal Medicine، جلد ۱۳، شماره ۲، صفحات ۴-۰
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عنوان انگلیسی Can cytokines response play a role in the treatment of fatal leptospirosis?
چکیده انگلیسی مقاله Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis. Methods: This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p< 0.05. Results: The patients' age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p< 0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022). Conclusion: Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis.
کلیدواژه‌های انگلیسی مقاله Leptospirosis, Inflammatory cytokine, treatment, outcome, IL10
نویسندگان مقاله | Mahmoud Sadeghi Zavare
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol


| Ahmad Alikhani
Department of Infectious Diseases, Antimicrobial resistance research center and communicable disease institute, Mazandaran University of Medical Sciences, Sari, Iran


| Kimia Mahmoodi


| Leila Delavaryan


| Ebrahim Salehifar
Department of clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.


| Ali Reza Rafiei
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
نشانی اینترنتی http://caspjim.com/browse.php?a_code=A-10-2136-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Infectious Diseases
نوع مقاله منتشر شده Original Article
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