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Iranian Journal of Immunology، جلد ۱۷، شماره ۴، صفحات ۳۱۳-۳۲۳
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عنوان انگلیسی Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population
چکیده انگلیسی مقاله Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) are believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors (TLR4 and TLR9) genes polymorphism in patients with Parkinson's disease in northern Iran. Methods: We extracted DNA from peripheral blood samples of 100 sporadic cases of Parkinson's disease and 100 healthy-matched controls with the mean age of 69.98 and 71.94 years, respectively. Subsequently, single-nucleotide polymorphisms (SNPs) of TLR4 and TLR9 were genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Results were confirmed employing Sanger sequencing. For the analysis of our data, we used SNPStats and SPSS 22 software. Results: Our findings indicated that the allele distribution for rs352140 of TLR9 gene was significantly different in the PD group compared with the healthy controls (p=0.02). Moreover, rs352140 T allele was observed to be correlated with PD reduced risk (TT + TC vs. CC). The dominant rs352140 model was approved as the most acceptable inheritance model for fitting the data (OR 0.41, 95% CI 0.23-0.75, p=0.0031). Additionally, haplotype analysis revealed a significant correlation between TLR9 polymorphisms and Parkinson's disease. Conclusion: The results of this study indicated that rs352140T of TLR9 gene was a protective factor in Parkinson's disease. Furthermore, this SNP could be regarded as a prognostic factor. However, this conclusion should be confirmed by further investigations.
کلیدواژه‌های انگلیسی مقاله Parkinson’s disease, Single-Nucleotide Polymorphisms (SNPs), Toll-Like Receptors 4, Toll-Like Receptors 9
نویسندگان مقاله Niloufar Sadat Miri |
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Payam Saadat |
Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Abbas Azadmehr |
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Morteza Oladnabi |
Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Abdolreza Daraei |
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

نشانی اینترنتی https://iji.sums.ac.ir/article_47232_2726e678e6c2e5aab31c5435b9dc5a9d.pdf
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