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Basic and Clinical Cancer Research، جلد ۱۲، شماره ۲، صفحات ۹۸-۱۰۸
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عنوان انگلیسی Opium Carcinogenicity: A Systematic Review of Experimental Studies
چکیده انگلیسی مقاله Several epidemiological studies have reported that regular use of opium can be associated with an increased risk of developing cancers, including oesophageal, laryngeal, bladder, lung, and gastric cancer. In this systematic review, we aimed at investigating whether experimental studies support this finding and, if yes, how opium consumption can cause cancer. Most of the articles that have studied opium or its derivatives have found it as a carcinogen. However, due to the complex composition, different forms, and various ways of opium use, further comprehensive experimental studies are required. Using modern genomic and epigenomic methods seems to help determine the molecular mechanisms underlying opium carcinogenicity.
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نویسندگان مقاله | Haniyeh Rafipour
Cancer Biology Research Center, Tehran University of medical sciences, Tehran, Iran.


| Elham Mohebbi
Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.


| Kazem Zendehdel
Cancer Biology Research Center, Tehran University of medical sciences, Tehran, Iran.


| Samad Muhammadnejad
-Cell-Based Therapies Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.


| Paria Akbari
School of medicine, Tehran University of Medical Science, Tehran, Iran.


| Saadeh Hashemi
Cancer Biology Research Center, Tehran University of medical sciences, Tehran, Iran.


| Kosar Nouri
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran


| Fatemeh Moradkhani
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Tahereh Barati
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran University of Medical Sciences.


| Saeid Amanpour
Cancer Biology Research Center, Tehran University of medical sciences, Tehran, Iran.
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/359
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