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Basic and Clinical Cancer Research، جلد ۱۳، شماره ۱، صفحات ۲۱-۲۹
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عنوان انگلیسی The Combination of Genistein and Imatinib has an Increased Effect on Cell Proliferation Inhibition in Philadelphia Positive Leukemia Cell Lines
چکیده انگلیسی مقاله Background: This study investigated the possible role of Genistein as a combination with Imatinib in controlling leukemia cell line proliferation. Methods: Three cell lines, K562, Kcl22, and CCRF, were cultured and analyzed for MTT, LDH, apoptosis, and cycle cell gene expression in the presence of different dosages of Imatinib and Genistein in combination or separately. Results: Data has shown a decrease in proliferation and an increase in apoptosis activity during combination treatment. LDH assay has shown no additional toxicity due to Genistein consumption in combination therapy. Analysis of the expression of responsible genes for cell cycle demonstrated both G1 (p53, p21 upregulation) and G2 (cdc25c downregulation) inhibitory effect in combination treatment. Conclusion: Altogether, this study suggests thatthe combination treatment of Imatinib and Genistein for leukemia cells resistant to Imatinib can increase treatment efficiency.
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نویسندگان مقاله | Ebrahim Azizi
Department of Genetics, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.


| Alireza Biglari
Department of Genetics, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Ali Abolhassani
Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Saeid Amanpour
Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Samad Muhammadnejad
Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Mahnaz Haddadi
Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Mojtaba Saffari
Department of Genetics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Ali Eslamifar
Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran


| Reza Shirkoohi
cancer institute of Iran- Cancer Research Center (CRC)
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/291
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