این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۶، صفحات ۵۸۶-۵۹۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anticonvulsive evaluation and histopathological survey of thalidomide synthetic analogs on lithium-pilocarpine-induced status epilepticus in rats
چکیده انگلیسی مقاله Background and purpose: Status epilepticus is a severe neurological disorder that can be life-threatening. Thalidomide and its analogs have shown promising results to confront pentylenetetrazole-induced seizures. This study aimed to evaluate the potential effects of three synthesized thalidomide derivatives on lithium-pilocarpine-induced status epilepticus. Experimental approach: To induce status epilepticus, rats received lithium chloride (127 mg/kg, i.p.) and pilocarpine HCl (60 mg/kg, i.p.) 20 h after lithium chloride injection. Thirty min before pilocarpine HCl administration, rats received hyoscine N-butyl bromide (1 mg/kg, i.p.) and concurrently one of the test compounds (5B, 5C, and 5D), diazepam, thalidomide, or vehicle (4% DMSO) to evaluate their anti-epileptic effects. Epileptic seizures scores were assessed through the Racine scale. Twenty-four h after injection of pilocarpine, brain samples were extracted for further histopathological evaluation. Findings/Results: Results revealed that among tested compounds (5B, 5C, and 5D), only compound 5C (1 mg/kg) exhibited excellent anti-epileptic activity comparable to diazepam (10 mg/kg). Compound 5D (100 mg/kg) only demonstrated comparable anti-epileptic activity to thalidomide (1 mg/kg). Compound 5B did not have any anti-epileptic activity even at the dose of 100 mg/kg. The histopathological survey showed that compound 5C has more neuroprotective effects than diazepam and thalidomide in the cortex of the brain. In the cornu ammonis 1 region, thalidomide had higher protective properties and in the cornu ammonis 3 and dentate gyrus areas, diazepam had higher efficacy to prevent necrosis. Conclusion and implications: Compound 5C is a good candidate for further studies regarding its potency, compared to thalidomide and diazepam.
کلیدواژه‌های انگلیسی مقاله Histopathology,Hippocampus,N-Phthalimide,Status epilepticus,Thalidomide.
نویسندگان مقاله | Arash Amanlou
2Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, I.R. Iran. 3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.


| Faezeh Eslami
2Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, I.R. Iran. 3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.


| Maryam Shayan
1Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, I.R. Iran.


| Pejman Mortazavi
2Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, I.R. Iran. 3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.


| Ahmad Reza Dehpour


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2092
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات