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Journal of Kerman University of Medical Sciences، جلد ۲۷، شماره ۵، صفحات ۳۸۹-۳۹۳
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عنوان انگلیسی Is there any Correlation between Cerebrospinal Fluid and Serum C-reactive Protein in Neonates Suspected to Meningitis?
چکیده انگلیسی مقاله Background: Meningitis is a common life threatening infection in neonatal period. Diagnostic value of CSF-CRP level in bacterial meningitis in children and adults has been studied worldwide, but there are limited studies on CSF-CRP in neonatal meningitis. This study conducted to assess any relation between CSF-CRP and plasma CRP levels and abnormal CSF findings in neonates suspected to meningitis. Methods: Seventy five hospitalized neonates suspected to meningitis were enrolled in this cross sectional study. All infants were gone through a complete sepsis workup including blood and CSF CRP. Results: CSF-CRP level had statistically significant correlation with serum WBC (p= 0.048) and also poor correlation with CSF protein level (p= 0.054). Serum CRP level had statistically significant correlation with CSF WBC (p= 0.008). Conclusion: No correlation found between CSF and serum CRP levels of patients in this study. Although, CSF-CRP is a rapid and easy to interpret test, it can be performed alongside CSF cytology and biochemical analysis, smear and culture as a confirmatory test for definite diagnosis of neonatal meningitis.
کلیدواژه‌های انگلیسی مقاله Newborn Meningitis Cerebrospinal fluid C, reactive protein Sepsis
نویسندگان مقاله Mandana Kashaki |
Assistant Professor of Neonatal-Perinatal Medicine, Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran

Elahe Norouzi |
Assistant Professor of Pediatrics, Neonatologist, Department of Pediatrics, Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Iran

Saeideh Heidarali |
Pediatrician, Iran University of Medical Sciences, Tehran, Iran

Parisa Mohagheghi |
Associate Professor of Pediatrics, Neonatologist, Department of Pediatrics, Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Iran

Mahmoud Soltani |
Assistant Professor of Neonatal-Perinatal Medicine, Iran University of Medical Sciences, Tehran, Iran

Hamid Karbalaei Hasani Karbalaei Hasani |
Pediatrics Resident, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_91471_d5aa768953aae7c8db10cbb1bb6370ce.pdf
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