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Journal of Kerman University of Medical Sciences، جلد ۲۸، شماره ۶، صفحات ۵۵۹-۵۶۷
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عنوان انگلیسی Detection of Genes Encoding Metallo-beta-lactamases in Carbapenem Resistant Acinetobacter baumannii
چکیده انگلیسی مقاله Background: Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. The aim of this study was to determine the antibiotic resistance pattern and the prevalence of metallo-beta-lactamase genes among nosocomial A. baumannii isolates from Qom/ Iran.Methods: For this study, a total of 108 A. baumannii isolates were collected from hospitalized patients in four teaching hospitals of Qom/ Iran. Antibiotic susceptibility profile of isolates was tested by Kirby-Bauer disc diffusion method and distribution of MBL genes among carbapenem-resistant isolates was determined by polymerase chain reaction (PCR) method.Results: According to the results, 97 (89.81%) isolates of 108 A. baumannii isolates were resistant to carbapenem. All isolates carried bla oxa-51like gene. Among carbapenem resistant isolates, 79.38% carried bla VIM and 1.03% had bla IMP genes. Among the MBL- producing isolates, 7 isolates were MDR, 73 ones were XDR and 5 isolates were PDR.Conclusion: This study also revealed that suceptibility to carbapenems in the population of A. baumannii isolates reduced and the bla VIM gene was the most prevalent metallo-beta-lactamase genotype among carbapenem resistant A. baumannii isolates in this area. MBL-producing A. baumannii in recent years has become a serious concern. Rapid identification and good infection control are requiered to reduce their impact.
کلیدواژه‌های انگلیسی مقاله Acinetobacter baumannii, Metallo-beta-lactamases, Carbapenem resistance, Polymerase Chain Reaction
نویسندگان مقاله Fatemeh Karami |
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran

Razieh Nazari |
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.

Hasan Adeli |
Department of Internal Medicine, School of Medicine, Spiritual Health Research Center, Qom university of Medical Sciences, Qom, Iran

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_91827_d9d7f9a22fdc132e68ce56ffdbf85ff8.pdf
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