این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۱۳، شماره ۵، صفحات ۷۱۲-۷۱۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of carvacrol on respiratory syncytial virus infection in mice model: caution in the use of herbal medicines
چکیده انگلیسی مقاله Background and Objectives: Respiratory syncytial virus (RSV) is one of the most common viruses associated with acute lower respiratory tract infections in infants, young children, and the elderly. Due to a lack of effective anti-viral drugs or vaccines, using an immunomodulatory strategy is probably the best option to decrease the burden of RSV disease. Here, we studied carvacrol as a known immunomodulator on RSV infection outcome in a mice model. Materials and Methods: Balb/c mice were infected by intranasal inoculation of RSV-A2, and treatment started daily 24 h after infection. Mice were sacrificed on day five after infection and experimental analyses were performed to study airway immune cell influx, CD4 and CD8 subtypes, cytokine/chemokine secretion, lung histopathology, and viral load. Results: Results showed that using carvacrol enhanced immune cell influx, cytokine/chemokine production, and virus titer, and aggravated lung pathology. Our result showed that carvacrol administration increased viral titer compared to the RSV-PBS group. Also, carvacrol significantly induced IFN-γ production and did not induce IL-10 production. Besides, carvacrol non-significantly increased lymphocytes and monocytes count but did not affect the neutrophil count. Conclusion: Carvacrol at the concentration of 80 (mg/kg) did not show immunomodulatory activity to alleviate the RSV infection outcome. Further research is needed to uncover the effects of the carvacrol intervention on virus replication and immune responses following RSV infection. Many herbal remedies in use contain carvacrol. However, the use of herbal remedies to treat viral respiratory infections such as RSV has to be performed with caution.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Marziye Faraji-Zonouz
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Farshad Khodakhah
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Forough Tavakoli
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Alireza Tahamtan
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran


| Masoumeh Tavakoli-Yaraki
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Farhad Rezaie
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Talat Mokhatri-Azad
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Vahid Salimi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/2939
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات