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Iranian Journal of Microbiology، جلد ۱۴، شماره ۱، صفحات ۱۱۲-۱۱۸
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عنوان انگلیسی Distribution of human papillomavirus genotypes in suspected women cytological specimens from Tehran, Iran
چکیده انگلیسی مقاله Background and Objectives: The human papillomavirus (HPV) is associated with more than 70% of the cervical neoplasm. The current study aims to evaluate the distribution of HPV genotypes in suspected women cytological specimens from Tehran, Iran. Materials and Methods: In the current cross-sectional study, HPV genotype prevalence was investigated in 433 subject women. DNA extraction was performed by High Pure Viral Nucleic Acid kit. A semi-automatically hybriSpot 24™ (HS24) setting was used for HPV typing and data interpreted by hybriSoft™ software according to instructions. Results: Pathologic data showed 181 (41.8%) had non-malignant lesions, 212 (49%) had inflammation and 40 (9.2%) reported LSIL in primary Pap-smear result. HPV was found in 143 (33%) specimens and the most comment high-risk and low-risk HPV types were HPV-16 and -6, respectively. Also, 62 (43%) were co-infected with multiple genotypes includes, 34 (24%) cases had co-infection with two HPV types, 17 (12%) cases had co-infection with three HPV types, 6 (4%) cases had co-infection with four HPV types and 5 (3%) cases had co-infection with five HPV types. There was statistically different domination on high-risk genotype in most of the co-infected samples (p< 0.01). Conclusion: Current study indicates that the lesion pathology assessment was significantly associated with the HPV infection (p< 0.01). Furthermore, the age group assessment shows that most of the HPV positive cases were 21 to 40 (p< 0.01). The HPV infection prevalence in the current study was 33% and the most frequently reported high-risk and low-risk HPV types were 16 and 6, respectively.
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نویسندگان مقاله | Alireza Tabibzadeh
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mahshid Panahi
Gastrointestinal and Liver Diseases Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Behnaz Bouzari
Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Taghi Haghi Ashtiani
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Farhad Zamani
Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, IranGastrointestinal and Liver Diseases Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Hadi Teimoori Arzati
Department of Veterinary, Islamic Azad University, Karaj Branch, Karaj, Iran


| Mohammad Hadi Karbalaie Niya
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Gastrointestinal and Liver Diseases Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/2984
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