|
|
Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۰، صفحات ۱۳۴۰-۱۳۴۵
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Ginkgo biloba extract protects early brain injury after subarachnoid hemorrhage via inhibiting thioredoxin interacting protein/NLRP3 signaling pathway |
|
| چکیده انگلیسی مقاله |
Objective(s): To investigate the effect of Ginkgo biloba extract EGb761 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its mechanism. Materials and Methods: The SAH rat model was constructed and pre-treated with EGb761.The neurological function, severity of SAH, water content of brain tissue, damage degree of the blood-brain barrier, related indexes of oxidative stress, and the level of inflammatory cytokines were compared among the groups. The expression of TXNIP/NLRP3 signaling pathway-related proteins in brain tissues was detected by Western blot.Results: After SAH modeling, the neurological function score was significantly reduced, the degree of brain injury, levels of oxidative stress, inflammatory factors, expression of NLRP3 and TXNIP were all increased. Compared with the SAH rats, the neurological function score of rats pre-treated by EGb761 was higher, the degree of brain injury, levels of oxidative stress and inflammatory factors, expression of NLRP3 and TXNIP were all lower. Conclusion: EGb761 could protect neurological injury after SAH and its mechanism may be that EGb761 could inhibit the activation of the TXNIP/NLRP3 signaling pathway and inflammatory reaction after oxidative stress. |
|
| کلیدواژه‌های انگلیسی مقاله |
Brain injury, Ginkgo biloba extract, Inflammation, Oxidative stress, Subarachnoid Hemorrhage |
|
| نویسندگان مقاله |
| Chuan Du
Neurosurgery Department, Zhangqiu District People’s Hospital, Jinan 250200, China
| Chao Xi
Cardiothoracic Surgery Department, Zhangqiu District People’s Hospital, Jinan250200, China
| Chunxiao Wu
Pharmacy Intravenous Admixture Services, Zhangqiu District People’s Hospital, Jinan 250200, China
| Jichang Sha
Neurosurgery Department, Zhangqiu District People’s Hospital, Jinan 250200, China
| Jinan Zhang
ENT Department, Zhangqiu District People’s Hospital, Jinan 250200, China
| Chao Li
Neurosurgery Department, Qilu Hospital of Shandong University, Jinan 250012, China
|
|
| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_16397.html |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|