|
|
Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۰، صفحات ۱۲۸۶-۱۲۹۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
The total flavonoids from Selaginella tamariscina (beauv.) Spring improve glucose and lipid metabolism in db/db mice |
|
| چکیده انگلیسی مقاله |
Objective(s): This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action.Materials and Methods: The db/db mice were divided into 5 groups: the normal group (NC), the diabetic group (DM), the gliclazide group (GZ), the DM+TFST (110 mg/kg), and the DM+TFST (220 mg/kg). The body weight, blood glucose, INS, GC, TC, TG, LDL, and HDL were detected. HE staining was used to observe the liver and pancreas. Urine was tested by UPLC-QTOF-MS to study the metabolic differences of each group, coupled with SIMCA-P13.0 for PCA and OPLS-DA analysis, to identify potential biomarkers, find the metabolic pathway. Western blot was used to examine liver tissue of mice for studying effect of TFST on the PPAR-γ/PI3K/GLU4 pathway.Results: TFST can reduce the weight and levels of TC, TG, and LDL-C, increase the level of GC in blood, and reduce the fat accumulation and inflammation in the liver, and repair the islet cell. 13 biomarkers were identified, they are mainly involved in amino acid metabolism, and purine and pyrimidine metabolism. The results of Western blot show TFST can improve the utilization rate of GLU4 by regulating PPAR-γ and PI3K expression in the liver of db/db mice.Conclusion: TFST can improve glucose and lipid metabolism of DM, which relates to regulation of the PPAR-γ/PI3K/GLU4 signaling pathway, and affect the amino acid metabolism, purine, and pyrimidine metabolism. |
|
| کلیدواژه‌های انگلیسی مقاله |
Biomarker Flavonoids Glucose metabolism, disorders Glucose transporter type 4 Lipid metabolism disorders 3, Phosphoinositide, dependent protein kinases PPAR gamma Selaginellaceae |
|
| نویسندگان مقاله |
| Xiaolan Wang
Henan University of Chinese Medicine, Zhengzhou, China|The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China
| Aozi Feng
First Affiliated Hospital, Jinan University, Guangzhou, China
| Peipei Yuan
Henan University of Chinese Medicine, Zhengzhou, China
| Yang Fu
Henan University of Chinese Medicine, Zhengzhou, China
| Zhiyao Bai
Henan University of Chinese Medicine, Zhengzhou, China
| Ning Zhou
Henan University of Chinese Medicine, Zhengzhou, China
| Zheng Xiaoke
Henan University of Chinese Medicine, Zhengzhou, China|The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China
|
|
| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_16328.html |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|