| چکیده انگلیسی مقاله |
Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The present study aimed to investigate the effects of diphenylheptanes (DPHs) extracted from A. officinarum rhizomes on ethanol-induced gastric ulcers in BALB/c mice.Materials and Methods: A total of 60 female BALB/c mice were divided into six groups as follows: negative control, which received sodium carboxymethyl cellulose; positive control, which received ethanol; treatment control, which received ethanol+ranitidine; ethanol+high dose of DPHs; ethanol+medium dose of DPHs; ethanol+low dose of DPHs. Different doses of DPHs were administered orally once daily for seven consecutive days before the animals were subjected to ethanol-induced gastric ulcers.Results: Various doses of DPHs significantly reduced Gastric ulcers index when compared with the positive control. DPHs treatments and treatment control increased the activity of superoxide dismutase; decreased the levels of inflammatory mediators, malondialdehyde, motilin, and gastrin; decreased the activity of inducible nitric oxide synthase and cyclooxygenase-2; and inhibited the expression of Toll-like receptor 4, myeloid differentiation factor 88, and nuclear factor-κB at the protein and mRNA levels. In addition, DPHs inhibited the expression of transient receptor potential vanilloid 1, calcitonin gene-related peptide, and increased the expression of substance P at the protein and mRNA levels. Conclusion: The protective effect of DPHs extracted from A. officinarum rhizomes against ethanol-induced gastric damages in mice suggests that the extract can be used as an auxiliary supplement for the prevention and treatment of gastric ulcers. |
| نویسندگان مقاله |
| Kaiwen Lin
School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China
| Huijuan Qu
School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China
| Yinfeng Tan
School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China
| Tang Deng
School of Pharmacy, Hainan Medical University, Haikou, China|Intervention Vascular Surgery of First Affiliated Hospital of Hainan Medical University, Haikou, China|Key Laboratory of Emergency and Trauma of Hainan Medical University, Ministry of Education, Haikou, China
| Bingmiao Gao
School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China
| Na Wei
School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China
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