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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۵، صفحات ۶۱۵-۶۲۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress |
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| چکیده انگلیسی مقاله |
Objective(s): To evaluate the pleiotropic potential and underlying mechanism of pantoprazole (PPZ) (common Proton Pump Inhibitors, PPIs) in type 2 diabetes mellitus (T2DM) -associated ischemia/reperfusion (I-R)-induced myocardial infarction which is still uncharted. Whereas some other PPIs have demonstrated their anti-diabetic, antioxidant, and anti-inflammatory potential. Materials and Methods: We evaluated the potential of coinciding treatment of PPZ (4 mg/kg/po/day for 8 weeks) in Wistar albino rats against STZ (50 mg/kg/IP) induced T2DM model and I-R provoked cardiac infarction model in diabetic and non-diabetic condition. Results: PPZ significantly inhibited the perturbed deviations in blood glucose concentration, HbA1c, C-peptide, plasma insulin, and ameliorated the lipid profile (dyslipidemia). PPZ protected myocardial tissue against lipid peroxidation by restoring the levels of serum TBARS and reduced NBT. The significant protective effects of PPZ were evident by ameliorating CKMB, LDH, cTnI, and myocardial oxidative stress in PPZ treated animals. Additionally, PPZ prominently reduced various proinflammatory cytokines release including TGF-β1, TNF-α, and IL-6. PPZ upsurges the bioavailability of nitrite/nitrate concentration which may pacify the impact of myocardial infarction in diabetic I-R injury. Conclusion: The consequences indicate that PPZ possesses a potent protective effect against diabetic I-R-induced myocardial infarction via suppressing oxidative stress, inflammation, and dyslipidemia-associated tissue damage. |
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| کلیدواژه‌های انگلیسی مقاله |
Cardiomyopathy, Diabetes Mellitus, Inflammatory cytokines, Myocardial I/R insult, Oxidative stress, Pantoprazole |
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| نویسندگان مقاله |
| Gaurav Taneja
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh-201303, India
| Arun Sharma
Cardiovascular Division, Department of Pharmacology, Amity University Haryana, Gurugram-122413, India
| Deepa Khanna
Rajendra Institute of Technology and Sciences (RITS), Sirsa, Haryana, India
| Satyendra Rajput
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh-201303, India|Gurukul Kangri Vishvidyalaya Haridwar, Uttarakhand, India
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_17816.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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