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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۲، صفحات ۲۱۴-۲۲۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats |
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| چکیده انگلیسی مقاله |
Objective(s): This study aimed to investigate the possible consequences of administering exogenous melatonin as prevention or treatment against tunicamycin-induced endoplasmic reticulum (ER) stress in the testicular tissue of rats. Materials and Methods: In this study, 42 adult Sprague Dawley rats, randomly divided into seven equal groups, were administered intraperitoneal tunicamycin to induce ER stress. Both prophylactic (PMel) and therapeutic melatonin (TMel) groups were administered melatonin for seven days. ER stress in the cell was detected through immunohistochemical and molecular analyses using GPR78 expression. Results: Increased oxidant levels and apoptosis rates were shown in testicular tissue because of ER stress. The sections in the melatonin-administered and control groups were similar, with melatonin-administered groups showing an increase in the antioxidant ratio. Histometric examinations revealed both TMel and melatonin applications reduced the diameter of the tubules. However, immunohistochemical and molecular analyses showed that PMel administration decreased the concentration of GRP78 more effectively than TMel. Conclusion: Applying melatonin prior to cell damage occurrence can be recommended for its effectiveness in protecting from tunicamycin-induced ER stress. |
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| کلیدواژه‌های انگلیسی مقاله |
Apoptosis, Endoplasmic reticulum stress, Endoplasmic reticulum chaperone BiP, Melatonin, Testis, Tunicamycin |
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| نویسندگان مقاله |
| Musa Tatar
Department of Histology and Embryology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, Turkey
| Ülker Eren
Department of Histology and Embryology, Faculty of Veterinary Medicine, Aydın Adnan Menderes University, Aydin, Turkey
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_19590.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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