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طب جانباز، جلد ۱۳، شماره ۳، صفحات ۱۹۵-۱۹۸
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عنوان انگلیسی Using Vascular Cell Adhesion Molecule-1 as a Biomarker for Detecting Progression of Different Types of Malignant Tumors
چکیده انگلیسی مقاله Aims: Vascular cell adhesion molecule-1 is a transmembrane glycoprotein closely related to tumorigenicity as well as tumor metastasis. It is also a well-known candidate for detecting tumors as a very common consequence of war-related symptoms. This study was designed to investigate the probability of using a cancer biomarker (VCAM-1) as an indicator for the progression of breast, lung, and bladder cancers. Materials & Methods: This experimental study was conducted on 15 to 89 years-old patients who attended the Middle Euphrates cancer center and the breast disease clinic in AL-Sadder Medical City teaching hospital in Al-Najaf Province, Iraq, for a checkup from September 2020 to January 2021. Eighty-eight samples were selected by random sampling method; 22 patients for each breast, lung, and bladder cancer group and 22 healthy subjects as control. An Enzyme-Linked Immunosorbent Assay (ELISA) was used to evaluate the concentration of VCAM-1. Data were analyzed by one-way ANOVA and Tukey's multiple comparison tests. Findings: The means±SE of VCAM-1 levels in control, breast, lung, and bladder cancer groups were 42.29±3.928ng/ml, 58.12±2.357ng/ml, 66.81±4.307ng/ml, and 82.85±7.292ng/ml, respectively. Serum VCAM-1 levels increased significantly in all groups compared to the control group (p< 0.05) except in breast cancer (p>0.05). There was a significant difference only between breast and bladder cancer groups (p< 0.05). Conclusion: The highest level of VCAM-1 is in the bladder cancer group; therefore, serum VCAM-1 can be used as an indicator for bladder cancer.
کلیدواژه‌های انگلیسی مقاله VCAM-1,Bladder Cancer,Breast Cancer,Biomarkers,Lung Cancer
نویسندگان مقاله | A. Zaki Jafar Al-Asady
Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Kufa, Kufa, Iraq


| I. Ali Hussein Al-Hilaly
Laboratory Investigation Department, Faculty of Science, University of Kufa, Kufa, Iraq
نشانی اینترنتی http://ijwph.ir/browse.php?a_code=A-10-1789-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده سلامت جانبازان یا معلولان
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