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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۵، شماره ۲، صفحات ۱۰۳-۱۱۳
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عنوان انگلیسی The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease
چکیده انگلیسی مقاله Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low serum levels of IgM, which may take more than a year to be restored. Materials and Methods: This is a retrospective, controlled and observational study that analyzed 51 patients with underlying hematological disease, who were diagnosed with sepsis or septic shock during the study period, to evaluate whether IgM-rich Ig replacement decreases the 30-day mortality. Results: Of the 51 patients, 35 patients received IgM-rich immunoglobulin (group A) and 16 (31%) received conventional therapy. Eleven (69%) patients in the control group were alive after 30 days compared to 11 (34%) patients in the intervention group, p= 0.013. Conclusion: There are no apparent benefits in the use of IgM-rich immunoglobulin in septic patients with hematological disease.  
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نویسندگان مقاله | Pedro Fernandes
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Flávia Russo
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Lucas da Silva
Faculdade de Ciências Médicas Santa Casa de São Paulo, São Paulo, SP, Brasil


| Lafayete Ramos
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Aline Simões
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Larissa Okada
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Jamilla Cavalcante
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Maricy Lopes
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Maria Cristina Macedo
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil


| Roberto da Silva
Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, Brasil
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1276
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