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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۵، شماره ۲، صفحات ۹۶-۱۰۲
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عنوان انگلیسی Comparison of Long-Acting G-CSF (PD-Lasta) with Short-Acting G-CSF (PD-Grastim) in Neutrophil Recovery Following Consolidation Chemotherapy with High-Dose Cytarabine in Acute Myeloid Leukemia: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Acute myeloid leukemia (AML) patients are often neutropenic as a result of their disease alone or following their chemotherapy. In this randomized clinical trial the efficacy of Iranian short-acting (PD-Grastim) and long-acting G-CSF (PD-Lasta) were compared in term of time to recovery from neutropenia in de novo AML patients following the consolidation chemotherapy. Materials and Methods: Patients (n = 51) received one or two courses of Cytarabine and Daunorubicin as an induction. If complete remission was achieved, the treatment was followed by high-dose Cytarabine as consolidation chemotherapy. Twenty four hours after the consolidation chemotherapy, patient were randomized to receive either daily short-acting G-CSF (PD-Grastim) (300 µg/kg) or single-dose long-acting G-CSF (PD-Lasta) (6 mg). Results: The median time to recovery of neutrophils was 11.00 and 13.00 days for short-acting G-CSF (PD-Grastim) (n=22) and long-acting G-CSF (PD-Lasta) (n=29) groups, respectively (U=186.5, P>0.05 two-tailed). Incidence of adverse effects was similar in both short-acting G-CSF (PD-Grastim) and long-acting G-CSF (PD-Lasta) groups. Conclusion: Overall, data show that Iranian long-acting G-CSF (PD-Lasta) was not significantly different with Iranian short-acting G-CSF (PD-Grastim).
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نویسندگان مقاله | Mohsen Esfandbod
Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Agha barazadeh
Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Mona Faraz
Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Fariba Zarrabi
Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Gholamreza Toogeh
Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1353
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