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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۶، شماره ۱، صفحات ۱-۸
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عنوان انگلیسی Serum Albumin Levels Strongly Predict Survival Outcome of Elderly Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab-Combined Chemotherapy
چکیده انگلیسی مقاله Background: In the current Japanese aging society, a high number of very elderly patients (age ranged from 80 to 93) with diffuse large B-cell lymphoma (DLBCL, most frequent hematological malignancy), who require chemotherapy are encountered. However, standard chemotherapy can result in severe adverse effects in elderly patients. Although various scoring systems are available to assess frailty, they are too complicated to immediately make a therapeutic decision, and studies on indications for chemotherapy in elderly patients are few. Materials and Methods: In the present study, we retrospectively analyzed the clinical records of 56 patients with DLBCL aged 80 or older who received R-CHOP or similar chemotherapy. Association of various clinical parameters, including performance status, stage, B symptom(s), laboratory data and relative dose intensity and survival outcomes was examined. Results: Pretreatment serum albumin level was identified as the only factor that predicts overall and progression-free survivals. Conclusion: We have concluded that very elderly DLBCL patients aged 80 or older with hypoalbuminemia may be unfit for standard chemotherapy, regardless of other factors. Alternative or palliative therapy should be considered for those patients.
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نویسندگان مقاله | Hiroto Kaneko
Department of Hematology, Aiseikai Yamashina Hospital, 19-4 Takehana-Shichouno-cho, Yamashina-ku Kyoto 607-8086, Japan


| Kazuho Shimura
Department of Hematology, Aiseikai Yamashina Hospital, 19-4 Takehana-Shichouno-cho, Yamashina-ku Kyoto 607-8086, Japan


| Mihoko Yoshida
Department of Hematology, Aiseikai Yamashina Hospital, 19-4 Takehana-Shichouno-cho, Yamashina-ku Kyoto 607-8086, Japan


| Yosuke Matsumoto
Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, 15-749 Honmachi, Higashiyama-ku, Kyoto 605-8601, Japan


| Tsutomu Kobayashi
Department of Hematology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan


| Hitoji Uchiyama
Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, 15-749 Honmachi, Higashiyama-ku, Kyoto 605-8601, Japan


| Junya Kuroda
Department of Hematology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan


| Masafumi Taniwaki
1) Department of Hematology, Aiseikai Yamashina Hospital, 19-4 Takehana-Shichouno-cho, Yamashina-ku Kyoto 607-8086, Japan 2) Center for Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1316
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