|
|
Iranian Journal of Otorhinolaryngology، جلد ۳۴، شماره ۲، صفحات ۹۵-۱۰۵
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke’s Edema and Those with Laryngeal Cancer |
|
| چکیده انگلیسی مقاله |
Introduction:The present study aimed to assess human leukocyte antigen (HLA) typing differences between smokers with Reinke’s edema and those with laryngeal squamous cell carcinoma (SCC). Materials and Methods:The HLA class I, II alleles were examined in 76 unrelated Iranian patients using low-resolution polymerase chain reaction with the sequence-specific primer (PCR-SSP) method. Results:The frequency of the HLA-A*36 allele and HLA-B*35 was significantly higher in patients with SCC. The frequency of HLA-DRB1*01 alleles in Reinke’s edema was significantly higher, as compared to that in others. In the volunteer group, HLA-DRB1*13 and HLA-DRB1*15 were significantly higher. Conclusions:As evidenced by the obtained results, HLA-A*36 was significantly higher in SCC, as compared to that in volunteers and Reinke’s edema patients. It can be concluded that being positive for HLA-A*36 increases the chance of SCC by three times. This result should be further investigated in cohort studies conducted on larger samples. Furthermore, HLA-A*24 was significantly higher in the volunteer group, as compared to that in other groups. The HLADRB1*01 was remarkably higher in Reinke’s edema, as compared to that in SCC. |
|
| کلیدواژه‌های انگلیسی مقاله |
Human leukocyte antigen, Hypertrophic edema, Iranian, Polymerase chain reaction sequence-specific primers, Reinke’s edema |
|
| نویسندگان مقاله |
| Farzad Izadi
ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.
| Aslan Ahmadi
ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.
| Farideh Hosseinzadeh
ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.
| Marjan Mirsalehi
ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.
| Yadollah Shakiba
Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
| Mohammad Ali Bahar
Department of Immunology, Iran University of Medical Sciences, Tehran, Iran.
| Maryam Balali
ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.
|
|
| نشانی اینترنتی |
https://ijorl.mums.ac.ir/article_19780.html |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|