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Iranian Journal of Otorhinolaryngology، جلد ۳۴، شماره ۲، صفحات ۷۱-۸۱
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عنوان انگلیسی Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect
چکیده انگلیسی مقاله Introduction:The main goal of our study was to describe the transcription factor (NF-κβ), angiogenetic factor (VEGF), and remodeling markers (MMP-9 and TIMP-4) of the cholesteatoma tissue compared to control skin tissue. There are still uncertainties how transcription, angiogenetic and remodeling factors affect the cholesteatoma course. Materials and Methods:Eight cholesteatoma tissue specimens were retrieved from children, seven – from adults, seven skin controls – from cadavers. Obtained material immunohistochemically were stained for NF-κβ, MMP-9, TIMP-4, VEGF. Non-para­metric statistic methods were used. Results:A statistically significant higher numbers of NF-κβ and TIMP-4 immunoreactive cells in the cholesteatoma compared to control group. A very strong positive correlation between MMP-9 and TIMP-4 was seen in the patient group. A strong positive correlation - between MMP-9 in matrix and MMP-9, VEGF in perimatrix, between TIMP-4 in matrix and TIMP-4 in perimatrix, NF-κβ in the matrix and VEGF; between TIMP-4 in perimatrix and NF-κβ in the matrix. Conclusions:Correlation between MMP-9 and TIMP-4 suggests that TIMP-4 in cholesteatoma tissue intercorrelates to MMP-9. TIMP-4 likely regulates the development of cholesteatoma. Disbalance between MMPs and TIMPs affects NF-κβ and causes uncontrolled cell proliferation and immune response in this tumor. There is a lack of VEGF strong expression in cholesteatoma perimatrix. 
کلیدواژه‌های انگلیسی مقاله Cholesteatoma, Transcription factor, Metalloproteases, Vascular Endothelial Growth Factor
نویسندگان مقاله | Kristaps Dambergs
Department of Otorhinolaryngology, Riga Stradins University, 16 Dzirciema Street, LV-1007, Riga, Latvia.


| Gunta Sumeraga
Department of Otorhinolaryngology, Riga Stradins University, 16 Dzirciema Street, LV-1007, Riga, Latvia.


| Māra Pilmane
Institute of Anatomy and Anthropology, Riga Stradins University, Kronvalda Boulevard 9, LV–1010 Riga, Latvia.
نشانی اینترنتی https://ijorl.mums.ac.ir/article_19776.html
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