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Iranian Biomedical Journal، جلد ۲۴، شماره ۵، صفحات ۳۰۹-۳۱۸
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چکیده فارسی مقاله
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عنوان انگلیسی Aerial Parts of Peucedanum chenur Have Anti-Cancer Properties through the Induction of Apoptosis and Inhibition of Invasion in Human Colorectal Cancer Cells
چکیده انگلیسی مقاله Background: The Peucedanum species have many pharmacological effects due to the presence of coumarins, flavonoids, phenolic compounds, and essential fatty acids in these species. In this study, for the first time, the anticancer activity of Peucedanum chenur methanolic extract via the induction of apoptosis and inhibition of invasion in HCT-116 human colon cancer cells was investigated. Methods:  P. chenur methanolic extract effect on HCT-116 cells viability and antioxidant activity were evaluated using MTT assay, DPPH, and iron chelating tests, respectively. Changes in mRNA expression level in a panel of relevant genes were assessed by the quantitative real-time PCR. Also, apoptosis was assessed by cell cycle analysis and Annexin V/PI method, and the effect on cell migration was tested using scratch test. Results: P. chenur methanolic extract increased significantly the expression of BAX while decreased the expression of BCL-2, AKT1, FAK, RhoA, and MMP genes compared to the control group. BAX/BCL-2 ratio and apoptosis elevated, whereas cell migration reduced significantly. Besides, our extract showed an appropriate antioxidant activity. Conclusion:  P. chenur may be introduced as a new chemopreventive agent in medicine due to its notable power in terms of induction of apoptosis and inhibition of invasion.
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نویسندگان مقاله | Saeed Yadegari
Research Center for Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran


| Massuod Saidijam
Research Center for Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran


| Mohammadreza Moradi
Research Center for Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran


| Dara Dastan
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Ali Mahdavinezhad
Research Center for Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-821&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2466434.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmaceutical Biotechnology
نوع مقاله منتشر شده مقاله کامل
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