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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۸۳۳-۸۴۰
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عنوان انگلیسی Wi-Fi (2.4 GHz) affects anti-oxidant capacity, DNA repair genes expression and apoptosis in pregnant mouse placenta
چکیده انگلیسی مقاله Objective(s): The placenta provides nutrients and oxygen to embryo and removes waste products from embryo’s blood. As far as we know, the effects of exposure to Wi-Fi (2.4 GHz) signals on placenta have not been evaluated. Hence, we examined the effect of prenatal exposure to Wi-Fi signals on anti-oxidant capacity, expressions of CDKNA1, and GADD45a as well as apoptosis in placenta and pregnancy outcome. Materials and Methods: Pregnant mice were exposed to Wi-Fi signal (2.4 GHz) for 2 and 4 hr. Placenta tissues were examined to measure the MDA and SOD levels. To measure SOD, CDKNA1, GADD45a, Bax, and Bcl-2 expressions were compared by real-time PCR analysis. TUNEL assay was used to assess apoptosis in placenta tissues. The results were analyzed by one-way analysis of variance (ANOVA) using Prism version 6.0 software. Results: MDA and SOD levels had significantly increased in exposed Wi-Fi signal groups (P-value< 0.05). Also, quantitative PCR experiment showed that SOD mRNA expression significantly increased in Wi-Fi signal groups. The data showed that CDKN1A and GADD45a genes were increased in Wi-Fi groups (P-value
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Homeira Vafaei
Maternal Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Ghazal Kavari
Maternal Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Hamid Reza Izadi
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Zare Dorahi
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Mehdi Dianatpour
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran|Department of Human Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Afrooz Daneshparvar
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Iman Jamhiri
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15510.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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