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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۶۹۹-۷۱۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Nigella sativa: Valuable perspective in the management of chronic diseases
چکیده انگلیسی مقاله Objective(s): Over the past 20 years, increasing interest in the use of medicinal plants as alternative or adjuvant treatments of several chronic diseases was observed. Accordingly, Nigella sativa or black cumin, a medicinal plant rich in bioactive compounds, has been used worldwide for food purposes or in traditional medicines. This paper aims to reveal N. sativa potential as adjunct treatment in cardiovascular diseases, diabetes, and hematological malignancies, due to their increasing prevalence and difficult management in everyday life.Materials and Methods: Databases like PubMed, Web of Science, Science Direct, Scopus, and Google Scholar were used to search the literature data. Keywords like anti-inflammatory effect, anti-oxidant effect, antihypertensive effects, hypolipidemic effects and hematological malignancies were used in combination with N. sativa.Results: Because of its numerous pharmacological actions, but especially for its anti-oxidant and anti-inflammatory properties, in vivo and in vitro studies demonstrated N. sativa positive effect against diabetes, hypertension, and hypercholesterolemia, all of them associated to cardiovascular diseases progression. Also, it was proved to have marked anti-proliferative, cytotoxic, pro-apoptotic, and anti-metastatic effects, in both solid cancers and hematological malignancies.Conclusion: N. sativa used as complementary treatment to classical medications can improve the management of several chronic diseases
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Raluca Maria Pop
Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania


| Adrian Pavel Trifa
Iuliu Hatieganu University of Medicine and Pharmacy, Department of Genetics, Cluj Napoca, Romania


| Ada Popolo
University of Salerno, Department of Pharmacy, Fisciano, Salerno, Italy


| Veronica Sanda Chedea
Research Station for Viticulture and Enology Blaj, Blaj, Romania


| Claudia Militaru
Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania


| Ioana Corina Bocsan
Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania


| Anca Dana Buzoianu
Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj Napoca, Romania
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15494.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2393603.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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