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Iranian Biomedical Journal، جلد ۲۴، شماره ۴، صفحات ۲۱۴-۲۱۹
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice
چکیده انگلیسی مقاله Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β independent fashion. The recombinant WW2/WW3 domains from Smurf2 molecule was demonstrated to increase TGF-β signaling while reducing arginase I gene expression. In this study, we aimed to examine the effects of this recombinant protein on CD4+CD25+/CD4+ proportion in the spleen of 4T1 mammary carcinoma-bearing BALB/c mice. Methods: Flow cytometry was used to evaluate CD4+CD25+ spleen cell populations of the tumor-bearing mice that received WW2/WW3 protein treatment and those of the control group. :Results: The results indicated a significant rise in CD4+CD25+/CD4+ ratio, along with an average increase in tumor mass of the subjects that underwent protein treatment. Conclusion: It can be inferred that the heightened CD4+CD25+/CD4+ proportion in the spleen of  protein treated  tumor-bearing mice can be the result of the increased TGF-β signaling despite the reduced arginase I expression.    
کلیدواژه‌های انگلیسی مقاله Arginase, Transforming growth factor-ꞵ, WW domains
نویسندگان مقاله | Hani Mosayebzadeh Roshan
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


| Seyed-Hosein Abtahi-Eivary
Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Gonabad University of Medical Sciences, Gonabad, Iran


| Hassan Shojaee-Mend
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


| Alireza Mohammadzadeh
Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Gonabad University of Medical Sciences, Gonabad, Iran


| Zahra Bahari Sani
Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Gonabad University of Medical Sciences, Gonabad, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-815&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2380495.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
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