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Basic and Clinical Cancer Research، جلد ۱۱، شماره ۴، صفحات ۳۳۶-۳۳۶
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عنوان انگلیسی Metformin efficacy on proliferation indices of tumoral cells among non-diabetic patient with invasive breast cancer referred to the Cancer Institute of Iran
چکیده انگلیسی مقاله Introduction: We conducted a non-randomized clinical trial and studied effect of metformin therapy on the level of Ki67, as a measure of proliferation of tumor cells. Methods: We design a prospective non-randomized clinical trial. Our primary endpoint was changes of Ki67. Patients neither had indication of neoadjuvant chemotherapy, nor reported being diagnosed as diabetes mellitus. They were followed up from time of biopsy to operation. Metformin (1500 mg/day) was prescribed in the intervention group after date of diagnosis until the date of operation. Control group were breast cancer patients who were not received metformin. Results: 25 patients received metformin for median time of 2.8 weeks. Controls were 20 early breast cancer patients who were followed up with no prescription from biopsy until operation. We could not find any statistically significant difference between two groups regarding baseline clinical/ tumor characteristics such as age, stage, grade, estrogen receptor, HER2 status or time and type of surgery. However, immunohistochemistry study showed decrease of median KI67 from 35.14 to 29.6 in the intervention group and increase from 24.5 to 30.6 in the control group. Both of these results were statistically significant. Although mild gastrointestinal symptoms were seen in approximately 50% of cases, generally patients tolerated metformin well. There was a correlation between metabolic factor of HOMA score and changes in KI67. Conclusion: Metformin prescription in the short period of time between biopsy and definitive surgery showed inhibition of breast cancer cell growth. We found relationship between metformin anti-proliferative effect and glucose and insulin metabolism.
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نویسندگان مقاله | Sanambar Seddighi
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran


| Maasoumeh Saberian
Department of Medical Oncology, Cancer Research Center, Cancer Institute of Iran, Tehran, Iran.


| Bita Behrouzi
Geisel School of Medicine at Dartmouth, Hanover, United States.


| Maasoumeh Najafi
Department of Surgical Oncology, Iran Cancer Institute, Tehran, Iran.


| Issa Jahanzad
Department of Pathology, Imam Khomeini Hospital, Iran Cancer Institute, Tehran, Iran.


| Ramesh Omranipour
Department of Surgical Oncology, Iran Cancer Institute, Tehran, Iran.
نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/336
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