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Avicenna Journal of Medical Biotechnology، جلد ۱۲، شماره ۲، صفحات ۱۳۲-۱۳۴
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عنوان انگلیسی Gene expression and levels of TGF-β in PBMC is associated with severity of symptoms in chronic heart failure
چکیده انگلیسی مقاله Background: TGF-β1 is known to promote cardiac remodeling and fibrosis during Congestive Heart Failure (CHF). In this study, an attempt was made to investigate expression of Transforming Growth Factor beta1 (TGF-β1) and relative expansion or contraction of regulatory T-cell (Tregs) population in peripheral blood of patients with Chronic Heart Failure (CHF). Methods: Real-time PCR assay was used to investigate expression and post-stimulation levels of TGF-β1 in cell culture supernatant of Peripheral Blood Mononuclear Cells (PBMC) of 42 patients with CHF and 42 controls. Flow cytometry was used to identify relative counts of CD4+CD25+FoxP3+ Tregs. Results: PBMCs in patients with CHF expressed higher levels of TGF-β1 compared to controls. Post-stimulation levels of TGF-β1 expression were significantly higher in New York Heart Association (NYHA) functional class IV patients compared to stage I patients. Tregs were significantly expanded in PBMC in CHF, while the CD4+­ helper T-cells were unchanged. Treg expansion was more significant in NYHA functional class I patients compared to class IV patients. Conclusion: Expansion of Treg population in CHF provides an extrinsic source for TGF-β1 production to induce reactive fibrosis and cardiac remodeling. Relative decrease in Treg population at advanced stages of CHF is indicative of a loss of regulatory characteristics in these cells and unopposed proinflammatory milieu. 
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نویسندگان مقاله | Samaneh Saadati
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Vajiheh Eskandari
Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran


| Farzaneh Rahmani
NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran


| Mohammad Jafar Mahmoudi
Department of Cardiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Zahra Rahnemoon
Cardiac Heart Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Zahra Rahmati
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Gorzin
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mona Hedayat
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Boston, USA


| Ali Akbar Amirzargar


| Nima Rezaei
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), , Boston, USA
نشانی اینترنتی http://www.ajmb.org/En/Article.aspx?id=20410
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