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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۶۴۵-۶۵۳
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عنوان انگلیسی Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats
چکیده انگلیسی مقاله Objective(s): Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately causes long time brain function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, brain edema, and inflammation in male rats with cerebral I/R. Materials and Methods: Sixty male Wistar rats (250-300 g) divided into 6 groups randomly with 10 in each: 1) Sham+Veh; rats submitted to the surgery without any I/R and received vehicle (10% DMSO in normal saline 5 ml/kg, gavages). 2) I/R+Veh; 3-5) I/R+EA; I/R rats received 50, 75 and 100 EA mg/kg, by gavages 3 times daily for one week. The cerebral I/R injury was induced by clamping the bilateral common carotid arteries for 20 minutes followed by reperfusion. Behaviors were tested one week after treatment, and brain tissue cytokines were measured by special ELISA kits. Results: Cerebral I/R disrupted BBB function (P
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نویسندگان مقاله | Khadijeh Hassonizadeh Falahieh
Department of Physiology, College of Sciences, Science and Research Branch, Islamic Azad University, Fars, Iran|Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran


| Alireza Sarkaki
Persian Gulf Physiology Research Center and Department of Physiology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran|Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran


| Mohammadamin Edalatmanesh
Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran


| Mohammad Kazem Gharib Naseri
Persian Gulf Physiology Research Center and Department of Physiology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran


| Yaghoob Farbood
Persian Gulf Physiology Research Center and Department of Physiology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15215.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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