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Nanomedicine Journal، جلد ۷، شماره ۲، صفحات ۱۲۴-۱۳۰
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عنوان انگلیسی Synergistic cellular toxicity and uptake effects of iodixanol conjugated to anionic linear globular dendrimer G2
چکیده انگلیسی مقاله Objective(s): Early diagnosis of cancer using noninvasive imaging techniques has been discussed in several recent studies. The present study aimed to assess the synergistic effects of iodixanol-conjugated polyethylene glycol (PEG)-citrate (anionic linear globular) dendrimer G2 on MCF-7 breast cancer cells and human embryonic kidney 293 (HEK293) cells. Materials and Methods: PEG-citrate dendrimer G2 was synthesized and purified. The product w::as char::acterized using atomic force microscopy (AFM), electron energy loss spectroscopy (EELS), dynamic light scattering (DLS). At the next stage, the product was conjugated to iodixanol, purified and lyophilized. The cytotoxic effects of the iodixanol, plain PEG-citrate dendrimer G2, and iodixanol-PEG-citrate dendrimer G2 complex were evaluated using methylthiazole-tetrazolium (MTT) assay on the MCF-7 and HEK293 cells. Inductively coupled plasma mass spectrometry (ICP MS) is a mass spectrometry technique, which applies inductively coupled plasma to ionize samples.Results: According to the obtained results, the uptake of PEG-citrate dendrimer G2 iodixanol increased significantly compared to iodixanol alone (P
کلیدواژه‌های انگلیسی مقاله Cellular Toxicity, Iodixanol, Linear Globular Dendrimer
نویسندگان مقاله | Mitra Kiani
Department of Radiopharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Paria Mojarrad
School of Pharmacy, Tehran University of Medical Sciences, International Branch, Tehran, Iran


| Mehdi Shafiee Ardestani
Department of Radiopharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_14531.html
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