| چکیده انگلیسی مقاله |
Objective(s): Bone tissue engineering is aimed at the fabrication of bone graft to ameliorate bone defects without using autografts or allografts. Materials and Methods: In the present study, the coprecipitation method was used to prepare hydroxyapatite (HA) nanoparticles containing nandrolone. To do so, 12.5, 25, and 50 mg of nandrolone were loaded into poly(lactic acid) (PLA)/nano-HA, and the freeze casting method was used to fabricate porous scaffolds. The morphology, mechanical strength, wettability, porosity, degradation, blood compatibility, and cellular response of the scaffolds were evaluated using various tests. For further investigation, the developed scaffolds were incorporated into the rat calvaria defect model, and their effects on bone healing were evaluated. Results: The obtained results indicated that the fabricated scaffolds had the approximate porosity of 80% and compress strength of 6.5 MPa. Moreover, the prepared scaffolds had appropriate hydrophilicity, weight loss, and blood compatibility. Furthermore, the histopathological findings demonstrated that the defects filled with the PLA/nano-HA scaffolds containing 25 mg nandrolone healed better compared to the other study groups.Conclusion: Therefore, it was concluded that the scaffolds containing nandrolone could be used in bone regeneration. |
| نویسندگان مقاله |
| Majid Salehi
Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran|Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
| Arman Ai
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Arian Ehterami
Department of Mechanical and Aerospace Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran
| Masoumeh Einabadi
Department of Biology, Islamic Azad University, Jahrom Branch, Jahrom, Iran
| Alireza Taslimi
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Armin Ai
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Hamta Akbarzadeh
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Ghazal Jabal Ameli
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Saeed Farzamfar
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran
| Sadegh Shirian
Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
| Nahal Azimi
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Faezeh Sadeghi
Dentistry Student, Scientific Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Naghmeh Bahrami
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran|Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
| Arash goodarzi
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
| Jafar Ai
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran
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