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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۳، صفحات ۳۴۴-۳۵۳
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عنوان انگلیسی Cardiovascular responses produced by resistin injected into paraventricular nucleus mediated by the glutamatergic and CRFergic transmissions within rostral ventrolateral medulla
چکیده انگلیسی مقاله Objective(s): Resistin, as a 12.5 kDa cysteine-rich polypeptide, is expressed in hypothalamus and regulates sympathetic nerve activity. It is associated with obesity, metabolic syndrome and cardiovascular diseases. In this study, we investigated the neural pathway of cardiovascular responses induced by injection of resistin into paraventricular nucleus (PVN) with rostral ventrolateral medulla (RVLM). Materials and Methods: Adult male rats were anesthetized with urethane (1.4 g/kg intraperitoneally). Resistin (3 µg/1 µl/rat) was first injected into PVN, and the glutamatergic, corticotrophin-releasing factor (CRF)-ergic and angiotensinogenic transmission was inhibited by injecting of their antagonist in RVLM. Arterial pressure (AP) and heart rate (HR) were monitored before and after the injection. Results: The results showed that resistin injection into PVN significantly increased AP and HR compared to control group and prior to its injection (P
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نویسندگان مقاله | Abolfazl Akbari
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran


| Gholamali Jelodar
Department of Physiology, School of Veterinary Medicine, Shiraz University
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14435.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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