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Iranian Journal of Dermatology، جلد ۵، شماره ۴، صفحات ۳-۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Interferon-γ production and Leishmanin skin test in non-healing cutaneous Leishmaniasis compared with healed individuals |
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| چکیده انگلیسی مقاله |
Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) and Leishmanin skin test (LST) between non-healing and healed patients of CL. Patients and Methods: Fifteen patients with non-healing CL suffering for more than two years, and eight individuals cured from CL were enrolled in this study. The rate of IFN-γ production by peripheral blood mononuclear cells assessed by ELISA and results of LST were compared in both groups. Results: The mean level of the IFN-γ production in non-healing patients and cured individuals were 729 pg/ml, and 4229 pg/ml, respectively (T- test, P< 0.01). Four patients in non-healing group had negative LST and all cured patients had positive LST. Conclusion: The low level of the IFN-γ in non-healing patients and high level of IFN-γ in healed individuals are in favour of the lack of TH1 response, which is usually seen in healed patients. Comparing the results of LST between two groups is not conclusive. |
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| کلیدواژه‌های انگلیسی مقاله |
Leishmaniasis, Healing, Interferon-γ |
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| نویسندگان مقاله |
H Mortazavi |
A Khamesipour |
Z Hallaji |
H Bakhshi |
A Miramin Mohammadi |
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| نشانی اینترنتی |
http://iranjd.ir/article_98453_33b81107b35999afd8091513316ac29d.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/94/article-94-2213786.pdf |
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| زبان مقاله منتشر شده |
en |
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