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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۴، شماره ۱، صفحات ۵۶-۷۱
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عنوان انگلیسی Serum Concentrations of Vitamin D, Calcium, Phosphorus and Trace Minerals in Adults and Children with Haemophilia A: Association with Disease Severity, Quality of Life, Joint Health and Functional Status
چکیده انگلیسی مقاله Background: To investigate the serum levels of 25(OH)D and minerals in adults and children with haemophilia A, and the possible association of these factors with Pediatric Haemophilia/Haemophilia Activities List (PedHAL/HAL), Haemophilia Joint Health Score (HJHS) and Haemophilia-specific quality of life (QoL) index this case-control study was conducted. Materials and Methods: Eighty five haemophilia A patients (HP) registered in Hemophilia Society of Lorestan province were recruited. Along with HP, sex and age matched healthy controls (HCs) were recruited. Linear regression was used to evaluate the possible relation between biochemical factors and other variables. One-way analysis of variance (ANOVA) was used to compare the biochemical factors between three or more independent groups. Results: Results indicated that serum zinc, phosphorus and magnesium were significantly lower, whereas, serum level of alkaline phosphatase (ALP) was statistically higher in HP compared with HCs. Other biochemical factors including calcium and parathyroid hormone (PTH) were not different between groups. Serum 25(OH) D was lower only in children with haemophilia and not in adults. Percentage of subjects who were vitamin D deficient was higher in HP vs. HCs (57.6% vs. 35.3%), and also this rate was higher in children with haemophilia vs. adults (77.8% vs. 48.3%). Lower serum concentrations of assessed minerals and vitamin D were associated with lower physical activity, poor QoL and worst joint health, and these associations were stronger in children. Conclusion: Present study indicated that serum levels of vitamin D and minerals were low in HP, and these low levels were associated with poor QoL, lower physical activity and worst joint health.
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نویسندگان مقاله | Amir Abbasnezhad
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Mehdi Habibi
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Babak Abdolkarimi
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Soodabeh Zare
Department of Biostatistics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Ezatollah Fazeli Moghadam
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Razieh Choghakhori
1) Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran 2)Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1136
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