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Iranian Journal of Immunology، جلد ۱۶، شماره ۴، صفحات ۳۲۱-۳۲۶
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عنوان انگلیسی IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis
چکیده انگلیسی مقاله Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. Methods: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. Results: 184 patients were enrolled in the study and in 35 of whom fungal rhinitis was confirmed. The levels of specific IgE in patients with fungal allergy were statistically significant compared to those in the control group (p< 0.000). However, there were no significant differences in IL-25 and IL-33 levels between fungal and none-fungal AR patients. Conclusion: Chronic fungal challenge might regulate innate system cytokines in severe persistent AR.
کلیدواژه‌های انگلیسی مقاله Allergic Fungal Sinusitis,Interleukin-25,Interleukin-33,IgE
نویسندگان مقاله Reza Abbasi |
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Kamiar Zomorodian |
Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Zahra Zare Shahrabadi |
Department of Parasitology and Mycology, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran

Farshid Saadat |
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Seyed Hesamedin Nabavizadeh |
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Hossein Esmaeilzadeh |
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Sohila Alyasin |
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی http://iji.sums.ac.ir/article_45974_7f08abfcbbdd2c245ea1ac6a9226c445.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/172/article-172-2175889.pdf
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