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Nanomedicine Journal، جلد ۷، شماره ۱، صفحات ۵۸-۶۴
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عنوان انگلیسی EEffects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity
چکیده انگلیسی مقاله Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.Materials and Methods: In this study, 36 male albino Wistar rats were randomly divided into six groups (n=6). The control subjects and animals poisoned with AlP (2 mg/kg) received treatment with and without nano-curcumin (100 mg/kg) and curcumin (100 mg/kg) for seven days. Mitochondria were isolated from the liver and analyzed in terms of lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol groups (TTGs), superoxide dismutase (SOD), and catalase activity. In addition, mitochondrial viability was assessed. Results: AlP caused a significant increase in the LPO levels, while significantly decreasing TAC, TTG, SOD, catalase activity, and mitochondrial viability compared to the controls (P
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نویسندگان مقاله | Akram Ranjbar
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Leila Gholami
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Hassan Ghasemi
Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran


| Nejat Kheiripour
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_13628.html
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