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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۲، صفحات ۲۰۶-۲۱۳
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Protection of renal damage by HMG-CoA inhibitors: A comparative study between atorvastatin and rosuvastatin
چکیده انگلیسی مقاله Objective(s): Hypercholesterolemia is a common metabolic disorder in developing and developed countries and is associated with the increased rates of chronic kidney disease (CKD). Statin therapy could reduce cholesterol synthesis as well as progression of CKD. Diversity between statins causes variety in pharmacokinetics and pharmacodynamics and also their pleiotropic effects. In the present investigation we aimed to evaluate the protective potentials of both atorvastatin (Ator) (as lipid-soluble statin) and rosuvastatin (Ros) (as water-soluble statin) against renal histopathological damages in the high cholesterol diet induced hypercholesterolemic rats (HCDIHR).Materials and Methods: Serum lipid profile, oxidized low density lipoprotein (OX-LDL), malondialdehyde (MDA), urea and creatinine levels, as well as renal histopathology were evaluated.Results: While Ros acted better than Ator to reduce serum low density lipoprotein cholesterol (LDL-C) (P
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Maryam Jabarpour
Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran|Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Nadereh Rashtchizadeh
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Amir Ghorbani Haghjo
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Hassan Argani
Urology and Nephrology Research Center, Beheshti University of Medical Sciences, Tehran, Iran


| Mahboob Nemati
Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Siavoush Dastmalchi
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Leila Roshangar
Stem Cell Research Center, Tabriz University of Medical Sciences. Tabriz, Iran


| Masoumeh Ranjbarzadhag
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mehran Mesgari-Abbasi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Nasrin Bargahi
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Davoud Sanajou
Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14336.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-2144617.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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