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Bulletin of Emergency and Trauma، جلد ۴، شماره Issue ۳، صفحات ۱۳۴-۱۴۰
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عنوان انگلیسی Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-:union: Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial
چکیده انگلیسی مقاله Objective: To determine the effects of platelet rich plasma PRP on healing rates of long bone non-:union: fracture.Method: This was a randomized double-blind placebo controlled clinical trial being performed in a 12-month period. We included 75 adult (>18 years) patients suffering from long bone (Femur, Tibia, Humerus and Ulna) non-:union: fracture who were randomly assigned to receive 5mL PRP (n=37) or 5mL normal saline as placebo (n=38) in the site of fracture after intramedullary nailing or open reduction and internal fixation (ORIF) along with autologous bone graft. Patients were followed each 45 days till 9 months and were evaluated both clinically and radiologically in each visit. The healing rate, failure rate, incidence of infection, mal-:union: and limb shortening were recorded and compared between groups after 9 months of follow-up.Results: The healing rate was significantly higher in PRP group compared to placebo (81.1% vs. 55.3%; p=0.025). The limb shortening was significantly higher in those who received placebo (2.61±1.5 vs. 1.88±1.2mm; p=0.030). Injection of PRP was also associated with lower pain scores (p=0.003) and shorter healing duration (p=0.046). The surgical site infection (p=0.262) and mal-:union: rate (p=0.736) were comparable between groups.Conclusion: Application of PRP along with autologous bone graft in the site of non-:union: of long bone after intramedullary nailing or ORIF results in higher cure rate, shorter healing duration, lower limb shortening and less postoperative pain. Higher infection rate might be a complication of PRP application.Keywords: Non-:union:; Long bone Fracture; Platelet rich plasma (PRP); Intramedullary nailing; Open reduction and internal fixation (ORIF).Clinical Trial Registry: This trial is registered with the Iranian Clinical Trials Registry (IRCT201208262445N1; www.irct.ir).
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نویسندگان مقاله Fariborz Ghaffarpasand |
Shiraz University of Medical Sciences

Mostafa Shahrezaei |
AJA University of Medical Sciences

Maryam Dehghankhalili |
Shiraz University of Medical Sciences

نشانی اینترنتی http://beat.sums.ac.ir/article_44329_f89d4ef6ff34c2a6c018bfbbfb7c698f.pdf
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