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Iranian Journal of Immunology، جلد ۱۶، شماره ۳، صفحات ۲۲۵-۲۳۴
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عنوان انگلیسی The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. Results: The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. Conclusion: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months.
کلیدواژه‌های انگلیسی مقاله Infant,Maternal Immunization,Pertussis Vaccine
نویسندگان مقاله Ayse Kilic |
Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Gulcin Otar Yener |
Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Aylin Yetim |
Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Mustafa Ozcetin |
Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Gulbin Gokcay |
Istanbul University Institute of Child Health, Istanbul, Turkey

Asuman Coban |
Department of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Zeynep Ince |
Department of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Beril Yasa |
Department of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Lutfiye Oksuz |
Department of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Funda Gungor Ugurlucan |
Department of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Nezahat Gurler |
Department of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

نشانی اینترنتی http://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/172/article-172-2060725.pdf
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زبان مقاله منتشر شده en
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