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Journal of Obstetrics, Gynecology and Cancer Research، جلد ۳، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی The Effect of a Single Preoperative Dose of Sublingual Misoprostol in Reducing Intraoperative Blood Loss after Total Abdominal Hysterectomy: A Single-Blind Randomized Controlled Trial
چکیده انگلیسی مقاله Aims: Postoperative hemorrhage is one of the most frequently cited complications of total abdominal hysterectomy (TAH). This study aimed to investigate the effect of a single preoperative dose of sublingual misoprostol on reducing blood loss during total abdominal hysterectomies. Materials & Methods: This study was a single-blind randomized controlled trial (RCT). The statistical population included all women who were candidates of hysterectomy in 2017 and 2018 in Iran. A total of 132 patients were randomly selected and classified into two groups of misoprostol (N=66) and placebo (N=66). Examining intraoperative blood loss was considered a primary measurement. Moreover, levels of hemoglobin before and 24 hours after the surgery, the need for a blood transfusion, febrile morbidity, and the duration of hospitalization were regarded as secondary measurement. The means of bleeding in the two groups were compared using a t-test. Findings: There were no significant differences between the two groups in the baseline characteristics (P< 0.05). After the surgery, the mean of hemoglobin values was lower in the placebo group compared to the misoprostol one, and this difference was statistically significant (P< 0.001). There was a significant difference in intraoperative blood loss between the two groups, and it was significantly higher in the placebo group (P< 0.001).  Conclusion: Taking a single preoperative dose of sublingual misoprostol is effective in reducing intraoperative blood loss after total abdominal hysterectomies. Additionally, this intervention led to a decline in hemoglobin.
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نویسندگان مقاله | Shayesteh Parashi
Associate Professor of Obstetrics and Gynecology, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran


| Vahideh Astaraei
Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Mansoureh Vahdat
Assistant Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Parisa Dini
Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


| Mahdis Mohammadianamiri
Fellowship of Gyneco-oncology, Department of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://jogcr.com/browse.php?a_code=A-10-71-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده زنان و زایمان
نوع مقاله منتشر شده پژوهشی اصیل
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