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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۵، صفحات ۴۴۱-۴۴۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of angiotensin 1-7 and losartan on renal ischemic/reperfusion injury in male rats
چکیده انگلیسی مقاله Ischemia/reperfusion (I/R) is a major cause of acute kidney injury. Several studies have shown that renin angiotensin (Ang) system and activation of Ang II type 1 receptor (AT1) are involved in various forms of kidney diseases. Likewise, Ang 1-7 as a physiologic antagonist of AT1 and losartan could possibly protect the kidney against I/R damage. Therefore, we investigated renal injury by administering the drugs before and after I/R. Fifty-four male Wistar rats were randomly assigned to five groups as follows. 1, Sham operated; 2, saline group (as a control group); 3, losartan group; 4, Ang 1-7group; and 5, Ang 1-7 + losartan simultaneously. It should be noted that groups 2-5 consisted of two separate I/R-induced subgroups both receiving medication where the first groups received the treatment 15 min before induction of I/R while the medications were given to the second groups immediately after induction of I/R. Twenty four h after I/R, blood samples were collected, and then levels of serum urea nitrogen (BUN), creatinine (Cr), nitrite, malondialdehyde (MDA), lactate dehydrogenase (LDH) and total antioxidant capacity (TAC) were measured. Likewise, nitrite, MDA and TAC were measured in the homogenized kidney tissues. After the induction of I/R, the BUN, Cr, LDH, and kidney tissue damage score increased. Administration of Ang 1-7 alone or simultaneously with losartan decreased the levels of aforementioned factors. Also,kidney MDA and nitrate levels significantly increased after I/R induction ( P < 0.05). According to the results of this study, it can be claimed that the effect of losartan in the presence of Mas receptor is statistically significant and kidney damage dramatically decreases.
کلیدواژه‌های انگلیسی مقاله Angiotensin 1-7,Ischemia/reperfusion,Losartan,Renal damage.
نویسندگان مقاله | Tahereh Safari
1School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, I.R. Iran.


| Mohamad Reza Shahraki
1School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, I.R. Iran.


| Saideh Miri
1School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, I.R. Iran.


| Nasime Mirakzehi Bakhshani
2School of Medicine, Department of Pathology, Zahedan University of Medical Sciences, Zahedan, I.R. Iran.


| Abbass Ali Niazi
1School of Medicine, Department of Physiology, Zahedan University of Medical Sciences, Zahedan, I.R. Iran.


| Gholam Reza Komeili
3School of Medicine, Department of Medical English, Zahedan University of Medical Sciences, I.R. Iran.


| Hossain Bagheri


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1933
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1991900.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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