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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۵، صفحات ۴۳۲-۴۴۰
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عنوان انگلیسی Phytochemical analysis of Holothuria leucospilota,a sea cucumber from Persian Gulf
چکیده انگلیسی مقاله Sea cucumbers are widely consumed in traditional medicine and food. These animals have a considerable secondary metabolite and also several potential biological activities. This study investigated the phytochemical and cytotoxic evaluation of Holothuria leucospilota (H. leucospilota) , a sea cucumber from Persian Gulf. The saponin composition of H. leucospilota was studied by different partitioning and chromatography methods such as thin layer chromatography (TLC), medium pressure liquid chromatography (MPLC) and high performance LC (HPLC).The marine sea cucumber Holostane-type triterpenoids (1-3) were characterized by physical and spectroscopic examination (1 and 2 dimensional neuclear magnetic resonance and mass experiments) with data analysis. The structure of compounds 1-3 identified as echinoside A, holothurine A, and 24-dehydroechinoside A, showed moderate cytotoxic activity with IC 50 values of 1.9 ± 0.07, 6.8 ± 0.23, and 2.57 ± 0.18 µg/mL against HeLa and 10.4 ± 0.32, 8.9 ± 0.24, and 4.4 ± 0.13 on HUVEC cell line, respectively. In conclusion, the holostane-type triterpenoids showed moderate cytotoxic activity against HeLa cell line and have a prosperous future to be introduced as a lead structure.
کلیدواژه‌های انگلیسی مقاله Holothuria,Persian Gulf,Saponin,Sea cucumber.
نویسندگان مقاله | Mohammad Reza Shushizadeh
3Department of Pharmacognosy, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Pardis Mohammadi pour
3Department of Pharmacognosy, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Mohaddeseh Mahdieh
3Department of Pharmacognosy, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Afsaneh Yegdaneh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1932
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1991899.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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