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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۵، صفحات ۳۷۸-۳۹۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach
چکیده انگلیسی مقاله Solidification of a preconcentrate lipid formulation namely self-nano emulsifying drug delivery system (SNEDDS) is required to achieve feasibility, flexibility, and a new concept of “dry nano-emulsion”.The purpose of this study was to assess the effect of SNEDDS loading and ethanol as a diluent on the solidification of pitavastatin supersaturable SNEDDS (S-SNEDDS). A 2 2 full factorial design approach with a center point addition as a curvature was implemented to determine the effect of S-SNEDDS loading and ethanol on the physical characteristics, namely flowability, compactibility, and drug release behavior. Vibrational spectra, thermal behavior, and morphology of solid S-SNEDDS formulation were also evaluated. The results indicated that there was no interaction between S-SNEDDS and carrier, based on vibrational spectra. However, thermal behaviors (enthalpy and weight loss) were depending on SNEDDS loading. Thereafter, the ethanol as a diluent of preconcentrated formulation had no effect on the morphology of carrier structure. However, the S-SNEDDS loading altered the structure of carrier owing to either solubilization or abrasion processes. The statistical model suggested that ethanol as diluent reduced the flowability, compactibility, and drug releases. Meanwhile, the liquid SNEDDS loading affected the reducing of flowability and compactibility. Finally, solidification without diluent and 20% lipid formulation load was recommended. In addition, it was very useful because of ease on handling, flexibility for further formulation, and desired characteristics of final solid dosage form.
کلیدواژه‌های انگلیسی مقاله Pitavastatin,Solidification,Solid SNEDDS,Supersaturable.
نویسندگان مقاله | Ilham Kuncahyo
3Drug Delivery and Pharmaceutical Technology, Pharmaceutics Research Group, Department of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta, Indonesia.


| Syaiful Choiri
4Department of Pharmaceutics, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.


| Achmad Fudholi
5Department of Pharmaceutical Chemistry, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.


| Abdul Rohman
4Department of Pharmaceutics, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.


| Ronny Martien


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1922
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1991893.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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